Fig. 6

The mechanism of AFAP1-AS1 regulating PC cell stemness. High expression of AFAP1-AS1 was found in PC cells, while down-regulation of AFAP1-AS1 enhanced the expression of miR-384. While up-regulation of miR-384 inhibits the expression of ACVR1, which suppresses PC cell proliferation and invasion. AFAP1-AS1, actin filament-associated protein 1 antisense RNA 1; ACVR1, activin receptor A type I; PC, pancreatic cancer; miR-384, microRNA-384