TY - JOUR AU - Xie, Chunfeng AU - Zhu, Jianyun AU - Wang, Xueqi AU - Chen, Jiaqi AU - Geng, Shanshan AU - Wu, Jieshu AU - Zhong, Caiyun AU - Li, Xiaoting PY - 2019 DA - 2019/01/28 TI - Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway JO - Journal of Experimental & Clinical Cancer Research SP - 39 VL - 38 IS - 1 AB - Tobacco smoke (TS) critically contributes to the development of hepatocellular carcinoma. Cancer stem cells (CSCs) induced by TS is an early event in the initiation of carcinogenesis. Tumor specific microenvironment including inflammatory factors is key mediator for maintaining the stemness of CSCs through various pathways such as p38 MAPK. However, the mechanisms of inflammatory factors in TS-induced acquisition of liver CSCs properties remain undefined. The aim of this study was to investigate the role of IL-33/p38 axis in long term TS-induced acquisition of hepatic CSCs properties in mouse liver tissues and human liver cells. SN - 1756-9966 UR - https://doi.org/10.1186/s13046-019-1052-z DO - 10.1186/s13046-019-1052-z ID - Xie2019 ER -