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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway

Fig. 4

SB 203580 suppressed the activation of p38 MAPK in TS-exposed liver tissues. Mice exposed to TS were treated with or without p38 MAPK inhibitor (SB 203580) for 12 weeks, and the activation of p38 MAPK was detected by tissue immunofluorescence staining (a). b Fluorescence intensity of p-p38 relative to FA or TS + DMSO group. c The expression levels of p-p38, p38 and AP-1 proteins, including p-c-Jun, c-Jun, JunD, p-c-Fos, c-Fos, and FosB, were detected by Western blotting. d-g Densitometric analyses of Western blotting for p-p-38/p-38 (d), p-c-Jun/c-Jun (e), JunD (f), p-c-Fos/c-Fos (g) and FosB (h) were measured after normalization to β-actin; six animal samples per group were used for the densitometric analysis. Data are expressed as mean ± SD. The significance was assessed with one-way ANOVA test. # P < 0.05, ## P < 0.01, compared with FA control; * P < 0.05, ** P < 0.01, compared with TS + DMSO group. FA = filtered air; TS = tobacco smoke

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