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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Tobacco smoke induced hepatic cancer stem cell-like properties through IL-33/p38 pathway

Fig. 7

Long term TS exposure-induced EMT was involved in p-38 activation and CSC-like properties. Mice exposed to TS were treated with or without p38 MAPK inhibitor (SB 203580) for 12 weeks. a Liver tissues were stained immunohistochemically for E-cad, ZO-1, Vimentin and N-cad. b-e Fold changes of E-cadherin (b), ZO-1 (c), Vimentin (d) and N-cadherin (e)-positive area in TS group relative to FA group. f Western blotting of E-cadherin and Vimentin in liver tissues. β-actin was served as the loading control. g-h The indicated proteins relative to β-actin were assessed by densitometric analysis; six animal samples per group were used for the densitometric analysis. Data are expressed as mean ± SD. The significance was assessed with one-way ANOVA test. # P < 0.05, ## P < 0.01, compared with FA control; * P < 0.05, ** P < 0.01, compared with TS + DMSO group. FA = filtered air; TS = tobacco smoke

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