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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC

Fig. 6

CTSL promoted IR-induced EMT in the presence of mut-p53 in vivo. a and b) Subcutaneous tumor xenograft models established using Flag, Flag-p53, and Flag-p53 (R273H) cells when irradiated or not. The tumor volumes were measured and the nude mice were weighed every 2 days until the mice were killed. The curves were shown respectively. c The tumors were collected and processed for Western blot analysis of E-cadherin, N-cadherin, and CTSL (left panel). The corresponding quantities of protein expression were shown (right panel). d Immunohistochemical staining was conducted to verify the expression and cellular location of CTSL and Vimentin in tumor tissues. Data were shown as mean ± S.D., n = 3, *P < 0.05, **P < 0.01, *** P < 0.001, Student’s t-test

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