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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression

Fig. 4

LINC00346 interacts with miR-188-3p in pancreatic cancer. a Prediction of target sites for miR-188-3p, miR-1224-3p, and miR-505-5p in LINC00346 based on the online program (http://www.targetscan.org/vert_71/). b Kaplan–Meier survival analysis of miR-188-3p, miR-1224-3p, and miR-505-5p expression in pancreatic cancer based on TCGA datasets (http://starbase.sysu.edu.cn/panCancer.php). c Determination of the effect of overexpression of miRs on the expression of LINC00346 in pancreatic cancer cells. *P < 0.05 vs. control miR; n.s. indicates no significance. d Luciferase reporter assay showed that miR-188-3p overexpression significantly suppressed the activity of the reporter containing wild-type LINC00346. *P < 0.05; n.s. indicates no significance. e The expression of LINC00346 and miR-188-3p in pancreatic cancer specimens (n = 24)

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