Fig. 7

BRD4 mediates the growth-promoting activity of LINC00346. a Western blot analysis of BRD4 protein levels in pancreatic cancer cells transfected with control siRNA (siCtrl) or BRD4-targeting siRNA (siBRD4). Numbers indicate fold change in BRD4 protein levels relative to control cells. b and c PANC-1 and Capan-1 cells transfected with indicated constructs were tested for proliferation (b) and colony formation (c). ^*P < 0.05. d Western blot analysis of BRD4 protein levels in pancreatic cancer cells transfected with indicated constructs. e LINC00346 depletion-induced gemcitabine sensitivity was reversed by overexpression of BRD4. ^*P < 0.05