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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway

Fig. 2

Knockdown of GK5 inhibits H1975 cell proliferation. a CCK8 assay on the gefitinib dose response in gefitinib-resistant H1975 and -sensitive PC9 cells. * p < 0.05 vs. the PC9 cells. b Western blotting on GK5 expression in gefitinib-sensitive PC9 and gefitinib-resistant H1975 cells. c RT-PCR on GK5 expression in H1975 cells transfected with GK5-shRNA (shGK5–1 or − 2) or negative control shRNA (shNEG). d Morphology of H1975 cells expressing shGK5–1, − 2 or shNEG and cultured in the presence of 1 μM gefitinib. e CCK8 assay on the viability of H1975 cells expressing shGK5–1, − 2 or shNEG and treated with gefitinib. The data are representative of three experiments. * p < 0.05 vs. shNEG

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