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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway

Fig. 6

GK5 knockdown suppresses PC9R cell proliferation by inhibiting EGFR/AKT/SREBP1/SCD1 signaling molecules. a Whole human cDNA array analysis. b Western blotting on protein levels of EGFR, p-AKT, AKT, survivin, PLK1, SREBP1, SCD1 and Bcl-2 in PC9R cells c CCK8 assay on cell proliferation of PC9R cells overexpressing EGFR and infected with viral particles expressing shGK5–1 and shNEG. d CCK8 assay on cell proliferation of PC9R cells transfected with shGK5–1, − 2 or shNEG and treated with YM155. * p < 0.05 vs. shNEG

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