Fig. 1From: FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21FBXO22 is overexpressed in HCC. (a) Real time PCR analysis of FBXO22 expression in one normal hepatic cell line and six HCC cell lines. GAPDH was used as a loading control. (b) Western blot analysis of FBXO22 expression in one normal hepatic cell line and six HCC cell lines. GAPDH was used as a loading control. (c) Dot chart of the expression of FBXO22 in 110 pairs of HCCs and matched tissues detected by IHC. The results are expressed as means ±SD. (d) Representative images of IHC staining with anti-FBXO22 (400×, magnification). (e) Kaplan-Meier overall survival curve of two HCC groups: FBXO22 (+), patients with high FBXO22 expression; FBXO22 (−), patients with low FBXO22 expression. (f) Kaplan-Meier disease-free survival curves of the two HCC groups: FBXO22 (+), patients with high FBXO22 expression; FBXO22 (−), patients with low FBXO22 expressionBack to article page