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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Fig. 1

FBXO22 is overexpressed in HCC. (a) Real time PCR analysis of FBXO22 expression in one normal hepatic cell line and six HCC cell lines. GAPDH was used as a loading control. (b) Western blot analysis of FBXO22 expression in one normal hepatic cell line and six HCC cell lines. GAPDH was used as a loading control. (c) Dot chart of the expression of FBXO22 in 110 pairs of HCCs and matched tissues detected by IHC. The results are expressed as means ±SD. (d) Representative images of IHC staining with anti-FBXO22 (400×, magnification). (e) Kaplan-Meier overall survival curve of two HCC groups: FBXO22 (+), patients with high FBXO22 expression; FBXO22 (−), patients with low FBXO22 expression. (f) Kaplan-Meier disease-free survival curves of the two HCC groups: FBXO22 (+), patients with high FBXO22 expression; FBXO22 (−), patients with low FBXO22 expression

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