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Table 1 Association of FBXO22 Upregulation with Clinicopathologic Features in 110 Primary HCCs

From: FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Features Total FBXO22 Expression P value
Normal Expression Over Expression
Sex
 Male 90 35 55 0.746
 Female 20 7 13
Age (years)
  ≤ 50 55 22 33 0.695
 >50 55 20 35
ALT
 <70 100 37 63 0.420
  ≥ 70 10 5 5
AST
 <70 96 37 59 0.839
  ≥ 70 14 5 9
Serum AFP (ng/ml)
 <400 56 29 27 0.003
  ≥ 400 54 13 41
Tumor size (cm) *
  ≤ 5 40 21 19 0.019
 >5 70 21 49
Tumor number
 Single 84 31 53 0.620
 Multiple 26 11 15
BCLC stage
 0 + A 70 31 39 0.140
 B + C 40 12 28
TNM stage
 I + II 81 34 47 0.171
 III + IV 29 8 21
Differentiation
 Well/moderate 71 27 44 0.964
 Poor 39 15 24
Vascular invasion
 Yes 88 38 50 0.031
 No 22 4 18
Tumor capsule
 Absent 53 16 37 0.096
 Present 57 26 31
Recurrence
 Yes 53 24 29 0.139
 No 57 18 39
  1. NOTE. Statistical significance (P < 0.05) is shown in bold
  2. * Tumor size was measured by the length of the largest tumor nodule