MicroRNA-34 family: a potential tumor suppressor and therapeutic candidate in cancer

Table 1 miR-34 expression in human solid tumors

Tumor type	miR-34 family member	Number of tumor samples	Expression level compared with normal tissues	Ref.
BC	miR-34 family	173	Down	[37]
BC	miR-34a	134	Down	[94]
ccRCC	miR-34a	45	Up	[107]
ccRCC	miR-34a, miR-34b	17	Up	[108]
Colon Cancer	miR-34a, miR-34c	10	Down	[27]
Colon Cancer	miR-34a	40	Down	[109]
Colon Cancer	miR-34 family	272	Up	[31]
CRC	miR-34a	100	Down	[25]
CRC	miR-34b/c	17	Down	[110]
CRC	miR-34a	109	Up	[32]
EHCC	miR-34a	27	Down	[81]
EOC	miR-34 family	83	Down	[111]
ESCC	miR-34a	16	Down	[112]
ESCC	miR-34b	88	Up	[113]
Gastric Cancer	miR-34a	164	Up	[114]
Gastric Cancer	miR-34a	20	Up	[115]
Gastric Cancer	miR-34a	39	Down	[116]
Gastric Cancer	miR-34b	72	Down	[117]
GBC	miR-34a	77	Down	[118]
Glioma	miR-34a	21	Down	[119]
Glioma	miR-34c	18	Down	[120]
HB	miR-34 family	78	Down	[51]
HCC	miR-34a, miR-34b	30	Down	[53]
HCC	miR-34 family	57	Up	[52]
HNSCC	miR-34a	15	Down	[121]
LSCC	miR-34a	69	Down	[122]
MTC	miR-34a	30	Up	[123]
NSCLC	miR-34a	30	Down	[43]
NSCLC	miR-34b	52	Down	[49]
NSCLC	miR-34a, miR-34c	33	Down	[45]
OC	miR-34a	133	Down	[71]
OSCC	miR-34a	35	Down	[124]
OSCC	miR-34b/c	15	Up	[125]
OSA	miR-34 family	80	Down	[54]
OSA	miR-34	34	Down	[56]
PCa	miR-34a	30	Down	[33]
PCa	miR-34 family	49	Down	[126]
PDAC	miR-34a	159	Down	[127]
PDAC	miR-34a	48	Up	[128]
Rectum Cancer	miR-34a	109	Up	[32]
SCLC	miR-34b	11	Down	[49]
SCLC	miR-34 family	6	Down	[50]
SGT	miR-34a	48	Up	[129]
UBC	miR-34a	30	Down	[130]

ccRCC clear cell renal cell carcinoma, EHCC extrahepatic cholangiocarcinoma, EOC epithelial ovarian cancer, ESCC esophageal squamous cell carcinoma, GBC gallbladder cancer, HNSCC head and neck squamous cell carcinoma, LSCC laryngeal squamous cell carcinoma, MTC medullary thyroid carcinoma, OC ovarian cancer, OCSS oral squamous cell carcinoma, OSA osteosarcoma, PDAC pancreatic ductal adenocarcinoma, SGT salivary gland tumor, UBC urothelial bladder cancer

ISSN: 1756-9966