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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: TRPM7 promotes the epithelial–mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling

Fig. 6

Inhibition of TRPM7 expression enhances the calcium-signaling inhibitor-mediated inhibition of migration, invasion and wound healing in ovarian cancer cells. (a) The migration, invasion and wound healing of SKOV3-sh, SKOV3-TRPM7-sh, OVCAR3-sh and OVCAR3-TRPM7-sh cells in the presence or absence of BAPTA-AM were tested for 24 or 48 h. (b) Similarly, the migration, invasion and wound healing of SKOV3 and OVCA3 cells in the presence or absence of 30 µg/ml MK886 and/or BAPTA-AM were tested for 24 or 48 h. Data are representative images or expressed as the mean ± SD of each group of cells from three separate experiments

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