Fig. 2

MiR-154-5p and miR-376b-3p manifested an anti-oncogene in both glioma tissues and cells, decreased SNHG1 inhibited the malignant behavior of glioma cells by targeting miR-154-5p and miR-376b-3p. Expression levels of miR-154-5p (a) and miR-376b-3p (g) in clinical normal brain (n = 5) and glioma samples (LGG and GBM, n = 530) were presented as a box- whisker plot. Data were obtained from TCGA data sets. **P < 0.01 vs. normal group. Expression of miR-154-5p (b) and miR-376b-3p (h) in glioma tissues of different grades and normal brain tissues (NBTs) which were all obtained from clinical cases. Expression of miR-154-5p (c) and miR-376b-3p (i) in HA, U87 and U251 cells. CCK-8 assay was performed to explore the proliferation effect of miR-154-5p (d) and miR-376b-3p (j) on glioma cells. Flow cytometry analysis of U87 and U251 cells apoptosis with altered miR-154-5p (e) and miR-376b-3p (k) expression. Effects of miR-154-5p (f) and miR-376b-3p (l) expression changes on migration and invasion of U87 and U251 cells. Scale bars represented 20 μm. Except for A and G, data above were presented as the mean ± SD (n = 5, each group). **P < 0.01 vs. pre-NC group, ^##P < 0.01 vs. anti-NC group