PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Table 1 Characteristics of the neuroblastoma cell lines used in this study

Cell line	MYCN ^a	11q^b	TP53 status and p53 expression^c	MDM2 expression^d	ALK status ^c	Number of cancer driver variants (genes)	Reference
BE-2C	amp	no del	C135F^e High expression	–	wt	908 (629)	[29, 50, 51]
CHP212	amp	no del	wt	–	wt	619 (354)	[29, 50]
CLB-GA	wt	no del	wt	–	R1275Q (rs113994087)	715 (394)	[29, 32]
LAN6	wt	del	wt	–	D1091N (rs864309584)	754 (444)	[11, 29, 51]
NBL-S	wt	del	wt	–	wt	755 (434)	[29, 50, 51]
NGP	amp	del	A159D^f C141W^f	High expression	wt	1120 (810)	[29, 50]
SK-N-DZ	amp	del	R110L^e (rs11540654) High expression	–	wt	733 (453)	[29, 50]
SK-N-SH	wt	no del	wt	–	F1174 L (rs863225281)	660 (388)	[29, 50]

amp amplified, del deletion, no del no deletion, wt wild type
^aResults obtained from the literature and confirmed by real-time PCR expression of MYCN
^bResults verified with analysis of heterozygosity and/or Fish analysis
^cResults obtained by whole-exome sequencing and confirmed by the literature
^dResults obtained by real-time PCR and confirmed by the literature
^eHomozygous mutation/variant
^fHeterozygous mutation/variant

ISSN: 1756-9966