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Table 1 Characteristics of the neuroblastoma cell lines used in this study

From: PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

Cell line MYCN a 11qb TP53 status and p53 expressionc MDM2 expressiond ALK status c Number of cancer driver variants (genes) Reference
BE-2C amp no del C135Fe
High expression
wt 908 (629) [29, 50, 51]
CHP212 amp no del wt wt 619 (354) [29, 50]
CLB-GA wt no del wt R1275Q (rs113994087) 715 (394) [29, 32]
LAN6 wt del wt D1091N (rs864309584) 754 (444) [11, 29, 51]
NBL-S wt del wt wt 755 (434) [29, 50, 51]
NGP amp del A159Df
C141Wf
High expression wt 1120 (810) [29, 50]
SK-N-DZ amp del R110Le (rs11540654)
High expression
wt 733 (453) [29, 50]
SK-N-SH wt no del wt F1174 L (rs863225281) 660 (388) [29, 50]
  1. amp amplified, del deletion, no del no deletion, wt wild type
  2. aResults obtained from the literature and confirmed by real-time PCR expression of MYCN
  3. bResults verified with analysis of heterozygosity and/or Fish analysis
  4. cResults obtained by whole-exome sequencing and confirmed by the literature
  5. dResults obtained by real-time PCR and confirmed by the literature
  6. eHomozygous mutation/variant
  7. fHeterozygous mutation/variant