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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53

Fig. 7

Absence of p53 did not affect the role of DRAM2 in cell migration and proliferation. a. Cell cycle analysis; b. MTT assay; c. Colony formation assay; d. Transwell migration were performed in the context of DRAM2 overexpression and downregulation in H1299 cells. p-values for differences in cells in G1 phase by cell cycle analysis for H1299 were DRAM2 vs PCMV6, p = 0.019, and SiDRAM2 vs NC, p = 0.009. p-values for differences in MTT assay data for the fifth day were DRAM2 vs PCMV6, p = 0.014, and SiDRAM2 vs NC, p = 0.001. The p-values for the colony formation assay were DRAM2 vs PCMV6, p = 0.0334, and SiDRAM2 vs NC, p = 0.0266. *p < 0.05, **p < 0.01, ***p < 0.001. e. Effects of DRAM2 expression levels on the expression of proteins associated with cell proliferation in H1299 cells f. Effects of DRAM2 expression levels on the expression of proteins associated with cell migration in H1299 cells

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