Fig. 4
Circ_0000190 inhibits progression of MM by inhibiting miR-767-5p. a qRT-PCR detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on the expression of miR-767-5p in MM. 1S and H929 cells. b The CCK8 assay detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on cell viability of H929 cells. c The CCK8 assay detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on cell viability of MM. 1S cells. d EdU labeling assay detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on cell proliferation. e Flow cytometry detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on cell cycle. f IF staining detects the effect of circ_0000190and sh-circ_0000190, miR-767-5p mimics and inhibitor on the expression of MAPK4. g Western blot analysis detects the effect of circ_0000190 and sh-circ_0000190, miR-767-5p mimics and inhibitor on the expression of MAPK4, CDK6, CDK4, Cyclin D1 and Cyclin E, p21Cip1. Different letters in the figure indicate statistically significant differences (P < 0.05)