Fig. 8
Circ_0000190 inhibits growth of human MM tumor in murine xenograft models. a Effect of subcutaneously injection of MM.1S and NCI-H929 cells transtected with circ_0000190 over-expression or sh-circ_0000190 on the tumor growth. b qRT-PCR analysis ofcirc_0000190 in MM.1S and NCI-H929 tumors models mice transfected with circ_0000190 over-expression or sh-circ_0000190. **, *** circRNA or sh-circRNA vs. control, P < 0.01, P < 0.001. c qRT-PCR analysis of miR-767-5p in MM.1S and NCI-H929 tumors models mice transfected with circ_0000190 over-expression or sh-circ_0000190. **, *** circRNA or sh-circRNA vs. control, P < 0.01, P < 0.001. d Western blot analysis of MAPK4, CDK6, CDK4, Cyclin D1 and Cyclin E, p21Cip1 in tumors subcutaneously injected with MM.1S and NCI-H929 cells transtected with circ_0000190 over-expression or sh-circ_0000190.Different letters in the figure indicate statistically significant differences (P < 0.05)