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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer

Fig. 1

Downregulated miR-7 is correlated with high RelA/p65 in GC. a miR-7 is downregulated whereas RelA/p65 mRNA is increased in GC. Expression of miR-7 and RelA/p65 mRNA was analyzed using the same human GC cohort from the NCBI/GEO/GSE13861 (Normal: normal gastric mucosa; Cancer: gastric cancer). The box plot indicated the log2 transformed mRNA median gene expression level in the tissues. b Correlation of miR-7 with RelA/p65 mRNA expression (n = 193, r = − 0.159, P = 0.027) in GC from NCBI/GEO/GSE26942. c Expression correlation between miR-7 and NFKB1/p50 (n = 193, r = − 0.126, P = 0.071, left panel), NFKB2/p52 mRNA expression (n = 71, r = 0.538, P = 0.074; right panel) in GC from NCBI/GEO /GSE26942 and GSE13861. d Expression correlation between miR-7 and Vimentin (n = 132, r = − 0.311, P = 0.001) mRNA expression in GC from NCBI/GEO/ GSE54129. e-g Expression correlation between miR-7 and MMP-2 (n = 255, r = − 0178, P = 0.001; e, left panel), MMP-9 (n = 132, r = − 0.340, P = 0.001; e, right panel), VEGF (n = 193,r = − 0.228, P = 0.001; f, VCAM-1 (n = 255, left panel, r = − 0.159, P = 0.011; g, left panel) and ICAM-1(n = 71,r = − 0.263, P = 0.023; g right panel,) mRNA expression respectively according to NCBI GEO database(GSE26253, GSE54532, GSE26942, GSE13861). The expression correlation was determined with Pearson’s correlation analysis. ** P < 0.01; *** P < 0.001

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