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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: EVI1 promotes epithelial-to-mesenchymal transition, cancer stem cell features and chemo−/radioresistance in nasopharyngeal carcinoma

Fig. 6

EVI1 upregulation predicted an unfavorable prognosis and contributed to chemo−/radioresistance in NPC cells. (a) High-level EVI1 expression was correlated with a shorter OS rate. (b) High-level EVI1 expression was correlated with a shorter PFS rate. (c) Knockdown of EVI1 increased NPC cell sensitivity to 5-Fu, while overexpression of EVI1 decreased NPC cell sensitivity to 5-Fu as revealed by an MTT assay. (d) EVI1 downregulation increased NPC cell radiosensitivity, while overexpression of EVI1 decreased the NPC cell sensitivity to irradiation as revealed by an MTT assay. (e) EVI1 expression was negatively associated with E-cadherin expression, but positively associated with N-cadherin and Vimentin expression.(f) expression was positively associated with Nanog, SOX2 and c-myc expression

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