Fig. 1

Downregulation of miR-223-3p promoted lung squamous cell cancer development. a Microarray analysis of miRNAs from different LSCC tissues that successfully formed xenografts (XG, n = 3) and tumor tissues that failed to form xenografts (no-XG, n = 3) were presented in a heatmap. Each column represents a microRNA, and each row represents a sample. The relative expression values are depicted according to the color scale. Red indicates high relative expression, and green indicates low relative expression. T: XG tumor tissues; C: no-XG tumor tissues. b qRT-PCR analysis of miR-223-3p expression of LSCC tissues and adjacent normal tissues. c Representative images of the ISH staining analyses of two different LSCC tissues and adjacent normal tissues using anti-miR-223-3p probe. d Compared with no-XG group, the miR-223-3p expression in XG group was significantly decreased. Each qRT-PCR experiment was performed in triplicate. **P < 0.01