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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Human bone marrow-derived mesenchymal stem cells promote the growth and drug-resistance of diffuse large B-cell lymphoma by secreting IL-6 and elevating IL-17A levels

Fig. 2

hBMSCs secreted IL-6 into the co-culture supernatants and the IL-6 level was higher in the DLBCL tumor microenvironment. a and b: Levels of IL-6 at different time points in the 1:1 co-culture supernatants of SU-DHL-2/4 cells alone, SU-DHL-2/4 cells with hBMSCs, or hBMSCs alone. Levels of IL-6 (c and d), PGE2 (e and f), IL-10 (g and h), IL-17A (i and j), TGF-β (k and l), and IL-1β (m and n) in the 72 h direct or indirect co-culture supernatants of SU-DHL-2/4 cells with or without hBMSCs at different ratios. o: Graph of IL-6 relative expression (relative IOD) detected by IHC from benign tissues (n = 48) and tumor tissues (n = 18). p IHC staining showed various intensities of IL-6 expression in the intercellular spaces of tumor cells or tumor infiltrating lymphocytes (× 400). The data shown represent one of three independent experiments. Error bars represent SD. Significance was determined using two-tailed independent-sample Student’s t/t′ test. (*P < 0.05; **P < 0.01, compared with the SU-DHL-2/4 group)

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