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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: H2S suppresses indoleamine 2, 3-dioxygenase 1 and exhibits immunotherapeutic efficacy in murine hepatocellular carcinoma

Fig. 6

H2S restricted tumor growth in H22 HCC-bearing mice. a Representative images of tumors and spleens from four groups of mice (L-1-MT group, N = 4, other groups, N = 9) after being euthanized at the endpoint of study. Tumors were arrayed according to tumor size from small to large. b H22 tumor growth curve of different groups of mice. c Tumor weight measured from four groups of mice after being euthanized at endpoint of study. d H&E staining of H22 tumors from four groups of mice (× 400 magnification). Representative immunostaining of Caspase 3+ and CD31+ in tumors from four groups of mice (× 200 magnification). e The IDO1 expression in H22 cells demonstrated by western blot. f, g Quantification of Caspase 3 and CD31 positive cells of H22 tumors from four groups of mice. L-1-MT group, N = 4, other groups, N = 9. Statistical significance was determined by one-way ANOVA followed by Dunnett’s test. *P < 0.05, **P < 0.01, ***P < 0.001, bars show the group mean ± SD

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