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Table 1 M1 vaccine expressing MC38 neoantigens (see Fig. 2)

From: Poly-specific neoantigen-targeted cancer vaccines delay patient derived tumor growth

  

WT Peptide

Neoantigen

  

#

Symbol

Seq

H2-Db

H2-Kb

Seq

H2-Db

H2-Kb

DAI

Imm.Resp.

1

Wbp7

SNFHFMCAR

39,828

499

SNFHFMCAL

7213

10

> 5

+

2

Hace1

QINAFLQGF

44,767

1128

QIYAFLQGF

37,598

39

> 5

+

3

Hdgfrp2

KGYPHWPAR

43,395

4131

KGYPHWPAL

12,706

33

> 5

–

4

Kpna6

CTLQFEAAW

34,408

1319

CTLQFEAAL

8030

42

> 5

–

5

Aurkaip1

RTRFLRRKV

45,504

6329

RTRFLRLKV

42,713

7062

1

–

6

Srebf2

HSFVDSVGF

33,887

3985

HSFVYSVGF

38,481

135

> 5

–

7

Mttp

TGYVERSPR

41,635

11,661

TGYVERSPL

9548

131

> 5

–

8

Nle1

MALSTDYAL

1982

1278

MALSTYYAL

407

46

> 5

+/−

9

Zbtb24

SLLEHMSLH

43,119

18,788

SLLEHMSLL

7649

265

> 5

–

10

Hnrnpf

GYVVKLRGL

42,720

3065

SYVVKLRGL

38,966

438

> 5

–

  1. Predicted binding are expressed as nM values according to NetMHC-4. Immunogenic neoantigens (+) and intermediate response (+/) are indicated. Bold residues in the peptide sequence are mutated