LRG-1 promotes pancreatic cancer growth and metastasis via modulation of the EGFR/p38 signaling

Table 1 Prognostic value of different risk factors

Risk factors	Univariate regression analysis			Multivariate regression analysis			Overall survival
	HR	95% CI	P value	HR	95% CI	P value	Mean ± SD, months	P value
LRG-1 expression
Group 1: Low	2.29	1.47–3.57	<0.001	2.30	1.43–3.71	0.001	28.66 ± 1.73	<0.001
Group 2: High	2.29	1.47–3.57	<0.001	2.30	1.43–3.71	0.001	18.13 ± 1.40	<0.001
Tumor stage
Group 1: Stage I	3.02	1.97–4.62	<0.001	2.48	1.59–3.87	<0.001	32.08 ± 2.53	<0.001
Group 2: Stage II							22.41 ± 1.37
Group 3: Stage III							10.08 ± 1.24
R1 resection
Group 1: Yes	2.87	1.23–6.66	0.015	2.16	0.89–5.25	0.089	12.50 ± 2.48	0.009
Group 2: No	2.87	1.23–6.66	0.015	2.16	0.89–5.25	0.089	24.88 ± 1.36	0.009
Carbohydrate antigen 125
Group 1: <35	2.04	1.25–3.32	0.004	1.39	0.82–2.34	0.219	26.06 ± 1.51	0.003
Group 2: ≥35	2.04	1.25–3.32	0.004	1.39	0.82–2.34	0.219	16.91 ± 2.06	0.003
Carbohydrate antigen 19–9
Group 1: <37	1.68	1.26–2.24	<0.001	1.42	1.06–1.90	0.020	31.01 ± 2.67	0.001
Group 2: 37–200							23.78 ± 1.55
Group 3: >200							18.00 ± 1.89

ISSN: 1756-9966