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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Clinical development of targeted and immune based anti-cancer therapies

Fig. 2

Mechanism of action of anti-VEGF/VEGFR drugs. Due to activation of VEGF signaling pathways in various cancers, several anti-cancer drugs have been developed to target the VEGF pathway. Aflibercept is a peptide-antibody directed at PIGF and VEGFA, while bevacizumab is a mAb specific for VEGFA. Ramucirumab is a mAb that targets the VEGFA receptor (VEGFR2). On the other hand, sorafenib is a tyrosine kinase inhibitor for VEGFR, primarily VEGFR2. Each of these drugs prevent oncogenic signaling by VEGF overexpression

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