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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Landscape of tumor suppressor long noncoding RNAs in breast cancer

Fig. 8

EPB41L4A-AS2 inhibits cell proliferation in breast cancer. a and b Compared with the overexpression of a control, the overexpression of EPB41L4A-AS2 significantly inhibited cell proliferation in UACC812 and BT549 cells, as measured by CCK-8 assays. c The knockdown of EPB41L4A-AS2 expression promoted cell proliferation in MDA-MB-453 cells, as measured by CCK-8 assays. de The overexpression of EPB41L4A-AS2 inhibited clone formation in UACC812 and BT549 cells. f The knockdown of EPB41L4A-AS2 expression increased clone formation in MDA-MB-453 cells. g and h Compared with the overexpression of a control, the overexpression of EPB41L4A-AS2 significantly promoted cell apoptosis in UACC812 and BT549 cells, as measured by flow cytometry detection. i The knockdown of EPB41L4A-AS2 expression suppressed cell apoptosis in MDA-MB-453 cells, as measured by flow cytometry detection. j Bcl-2 expression was reduced, and Bax expression was increased in UACC812 and BT549 cells overexpressing EPB41L4A-AS2. k The knockdown of EPB41L4A-AS2 expression increased Bcl-2 expression and reduced Bax expression in MDA-MB-453 cells. **P < 0. 01; *P < 0.05. Data represent at least three independent experiments

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