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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2

Fig. 2

LINC00968 contributes to inhibition of the Wnt2/β-catenin signaling pathway, elevated E-cadherin level and downregulated Vimentin level. a the mRNA expression of β-catenin, GSK3β and Vimentin in MCF-7/ADM cells after plasmid delivery in each group as measured by RT-qPCR. b protein bands of β-catenin/p-β-catenin, GSK3β/p-GSK3β and Vimentin/p-Vimentin in MCF-7/ADM cells after plasmid delivery of each group as determined by Western blot analysis. c histogram of levels of β-catenin/p-β-catenin, GSK3β/p-GSK3β and Vimentin/p-Vimentin in each group. d protein bands of LINC00968 in MCF-7/ADM cells after plasmid delivery of each group. e LINC00968 protein level in each group detected by Northern blot analysis. f the mRNA expression of β-catenin, GSK3β and Vimentin in KPL-4/ADM cells after plasmid delivery in each group as measured by RT-qPCR. g protein bands of β-catenin/p-β-catenin, GSK3β/p-GSK3β and Vimentin/p-Vimentin in KPL-4/ADM cells after plasmid delivery of each group as determined by Western blot analysis. h histogram of levels of β-catenin/p-β-catenin, GSK3β/p-GSK3β and Vimentin/p-Vimentin in each group. i protein bands of LINC00968 in KPL-4/ADM cells after plasmid delivery of each group as evaluated by Northern blot analysis. j histogram of LINC00968 protein level in each group. *p < 0.05 vs. the control group; #p < 0.05 vs. the blank and NC groups; &p < 0.05 vs. the LINC00968 vector + WNT2 vector group

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