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Table 3 IC50 levels of ADR, Taxel and VCR is reduced in MCF-7/ADM and KPL-4/ADM cells after plasmid delivery

From: RETRACTED ARTICLE: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2

Group

ADR

Taxel

VCR

MCF-7

 Control

8.68 ± 0.94

1.26 ± 0.09

0.89 ± 0.07

 Blank

125.57 ± 10.56*

8.89 ± 0.57*

14.02 ± 1.14*

 NC

121.62 ± 11.04*

8.54 ± 0.62*

13.14 ± 1.03*

 LINC00968 vector

70.59 ± 6.34*#&

5.66 ± 0.43*#&

7.21 ± 0.52*#&

 si-LINC00968

189.45 ± 15.24*#

22.46 ± 1.54*#

38.65 ± 2.78*#

 WNT2 vector

201.32 ± 16.04*#&

24.16 ± 1.61*#&

40.51 ± 2.94*#&

 si-WNT2

67.89 ± 4.57*#

5.28 ± 0.41*#

7.63 ± 0.53*#

 LINC00936 vector + WNT2 vector

158.32 ± 13.56*#

15.16 ± 1.38*#

26.31 ± 2.59*#

KPL-4

 Control

9.34 ± 1.08

1.57 ± 0.11

0.97 ± 0.09

 Blank

132.41 ± 11.57*

9.94 ± 0.68*

17.05 ± 1.24*

 NC

139.57 ± 12.01*

10.05 ± 0.71*

16.27 ± 1.15*

 LINC00968 vector

80.27 ± 8.45*#&

5.79 ± 0.53*#&

8.38 ± 0.73*#&

 si-LINC00968

209.72 ± 15.37*#

23.67 ± 1.63*#

41.59 ± 3.01*#

 WNT2 vector

213.47 ± 16.68*#&

26.41 ± 1.74*#

43.92 ± 3.26*#&

 si-WNT2

76.42 ± 7.83*#

6.04 ± 0.55*#

9.07 ± 0.81*#

 LINC00936 vector + WNT2 vector

174.83 ± 14.27*#

16.72 ± 1.48*#

31.24 ± 2.91*#

  1. Note: *p < 0.05 vs. the control group; # p < 0.05 vs. the blank and NC groups; & p < 0.05 vs. the LINC00968 vector group. ADR adracalin, VCR Vincristine, NC negative control, WNT2 Wingless-type MMTV integration site family member 2, LINC00968 LINC00968 long non-coding RNA LINC00968