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Table 3 IC50 levels of ADR, Taxel and VCR is reduced in MCF-7/ADM and KPL-4/ADM cells after plasmid delivery

From: Long non-coding RNA LINC00968 attenuates drug resistance of breast cancer cells through inhibiting the Wnt2/β-catenin signaling pathway by regulating WNT2

Group ADR Taxel VCR
MCF-7
 Control 8.68 ± 0.94 1.26 ± 0.09 0.89 ± 0.07
 Blank 125.57 ± 10.56* 8.89 ± 0.57* 14.02 ± 1.14*
 NC 121.62 ± 11.04* 8.54 ± 0.62* 13.14 ± 1.03*
 LINC00968 vector 70.59 ± 6.34*#& 5.66 ± 0.43*#& 7.21 ± 0.52*#&
 si-LINC00968 189.45 ± 15.24*# 22.46 ± 1.54*# 38.65 ± 2.78*#
 WNT2 vector 201.32 ± 16.04*#& 24.16 ± 1.61*#& 40.51 ± 2.94*#&
 si-WNT2 67.89 ± 4.57*# 5.28 ± 0.41*# 7.63 ± 0.53*#
 LINC00936 vector + WNT2 vector 158.32 ± 13.56*# 15.16 ± 1.38*# 26.31 ± 2.59*#
KPL-4
 Control 9.34 ± 1.08 1.57 ± 0.11 0.97 ± 0.09
 Blank 132.41 ± 11.57* 9.94 ± 0.68* 17.05 ± 1.24*
 NC 139.57 ± 12.01* 10.05 ± 0.71* 16.27 ± 1.15*
 LINC00968 vector 80.27 ± 8.45*#& 5.79 ± 0.53*#& 8.38 ± 0.73*#&
 si-LINC00968 209.72 ± 15.37*# 23.67 ± 1.63*# 41.59 ± 3.01*#
 WNT2 vector 213.47 ± 16.68*#& 26.41 ± 1.74*# 43.92 ± 3.26*#&
 si-WNT2 76.42 ± 7.83*# 6.04 ± 0.55*# 9.07 ± 0.81*#
 LINC00936 vector + WNT2 vector 174.83 ± 14.27*# 16.72 ± 1.48*# 31.24 ± 2.91*#
  1. Note: *p < 0.05 vs. the control group; #p < 0.05 vs. the blank and NC groups; &p < 0.05 vs. the LINC00968 vector group. ADR adracalin, VCR Vincristine, NC negative control, WNT2 Wingless-type MMTV integration site family member 2, LINC00968 LINC00968 long non-coding RNA LINC00968