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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas

Fig. 3

TFE3 fusion proteins fail to co-localize with the lysosomal protein LAMP2. Renal carcinoma cell lines including HK2, UOK109 and UOK120 were treated with PP242 (4 μM) or torin1 (4 nM) or left untreated (Control). a to f Cells were stained with antibodies against TFE3 (red) and LAMP (green) followed by immunofluorescence photomicrographic analysis. (g) The merging of the red and green fluorescence signals shown in a to f were quantified with Image-pro Plus. Scale bar, 50 μ

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