Fig. 9From: TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomasTFE3 fusions promote the expression of 4EBP3 after mTORC1 inhibition. (a to d) 786-O, HK-2, UOK109 and UOK120 cells were treated with mTOR inhibitor (PP242) or DMSO (Control) for 24 h. The expression of 4EBPs were determined by q-PCR, and GAPDH was used as an internal control. (e, f) The expression of 4EBPs were detected by q-PCR after 24 h treatment with mTOR inhibitor (Torin1) or left untreated (Control) in UOK109 and UOK120 cells. (g) The fold-change of 4EBP3 in 786-O, UOK109 and UOK120 cells compared with HK-2. Data were presented as the mean ± SEM. *P < 0.05, **P < 0.01. The unpaired two-tailed Student’s t-test was used to calculate P valueBack to article page