Fig. 6
HOXD-AS1/miR-186-5p/PIK3R3 is a clinically relevant pathway. a Pearson correlation showing significant inverse correlation between HOXD-AS1 and miR-186-5p in 200 EOC tissues. b Pearson correlation showing significant inverse correlation between miR-186-5p and PIK3R3 in 200 EOC tissues. c Pearson correlation showing significant positive correlation between HOXD-AS1 and PIK3R3 in 200 EOC tissues. d RNA ISH assay of HOXD-AS1, miR-186-5p, PIK3R3 in HOXD-AS1 high expression ovarian cancer sample and HOXD-AS1 low expression ovarian cancer sample. e, f Kaplan Meier survival curve showing significantly poorer progression-free (e) and overall (f) survival in patients who showed high HOXD-AS1, low miR-186-5p and high PIK3R3 compared to patients who showed the reciprocal expression of these three factors. g Diagram summarizing the mechanism of action of HOXD-AS1/miR-186-5p/PIK3R3 on EMT in EOC cells