Fig. 4

Indo5 demonstrates anti-tumor activity and improves overall survival in a liver orthotopic mouse model. (a) The effect of Indo5 on the growth of orthotopic HepG2 cell xenografts. Mice bearing tumor xenografts were intraperitoneally injected with the indicated doses of Indo5 once daily for 3 weeks. Representative vehicle- and Indo5-treated HepG2 tumors are shown. The tumor weights were measured (b). (c) Therapeutic effects of Indo5 on survival of mice bearing MHCC97H orthotopic tumors. Mice bearing MHCC97H orthotopic tumors were administered with the indicated doses of Indo5 or 50 mg/kg Sorafenib once daily by oral gavage. Tumor-bearing mice were sacrificed when they became moribund. Kaplan–Meier survival analysis is shown