Fig. 1
From: MicroRNA-137 reduces stemness features of pancreatic cancer cells by targeting KLF12
miR-137 inhibits pancreatic cancer cell stemness in vitro. a miR-137 upregulation dramatically decreased the size and number of spheres formed in AsPC-1 and PANC-1 cell cultures, while anti-miR-137 had the opposite effect (p < 0.05). b-c Overexpression of miR-137 decreased the CD133+ population in cultured AsPC-1 and PANC-1 cells. In contrast, anti-miR-137 increased the CD133+ population in both cell lines (p < 0.05).d-e Overexpression of miR-137 markedly downregulated the expression of pluripotency-related mRNAs and proteins (p < 0.05), whereas miR-137 knockdown significantly upregulated the expression of these markers (p < 0.05)