Fig. 4
From: The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo
The effect of DMAMCL as a single agent or in combination with VCR on tumor-growth and mice-survival. RD, RH18, RH30, and RH41 cells were injected into mice. Mice with tumors were treated with vehicle, DMAMCL (75 or 100 mg/kg/d), VCR(0.8 mg/kg) or DMAMCL (75 or 100 mg/kg/d) with VCR(0.8 mg/kg) for 21 days. The dimension of the tumor volume was measured three times a week by digital caliper. The tumor volume was calculated as L*W2/2 (L = length, millimeter; W = width, millimeter). a Tumor volumes from control and treatment groups were compared when the last mouse in each group was euthanized. Bar, SE, *, P < 0.05; **, P < 0.001, RD (n = 9), RH18 (n = 8), RH30 (n = 11), and RH41 (n = 9). b Survival curve was plotted by Kaplan–Meier analysis. *, P < 0.05; **, P < 0.001, treatment groups versus control group, RD (n = 9), RH18 (n = 8), RH30 (n = 11), and RH41 (n = 9). c Tumor volumes from control and treatment groups were compared when the last mouse in each group was euthanized. Bar, SE, *, P < 0.05; **, P < 0.001, RD (n = 9), RH18 (n = 8), RH30 (n = 11), and RH41 (n = 9)