Fig. 8

Overexpression of WISP2 inhibits tumor growth in vivo. a, Tumor volumes were measured in nude mice after injection with Eca109 cells with WISP2 overexpression. b, Tumor sizes in nude mice after injection with Eca109 cells with WISP2 overexpression were photographed. c, Tumor weights were measured in nude mice after injection with Eca109 cells with WISP2 overexpression. d, Western blot analysis was used to measure the expression of WISP2, E-cadherin, ERK1/2, and Slug in tumor tissues. e, Tumor sizes in nude mice after injection with Eca109 cells with WISP2 downregulation were photographed (Top panel). Tumor weights were measured in these mouse tissues (Bottom panel).f, Western blot analysis was used to measure the expression of WISP2, E-cadherin, ERK1/2, and Slug in tumor tissues.g, A flowchart to show how WISP2 regulates the expression of E-cadherin, ERK1/2, and Slug in ESCC