Fig. 7

Zoledronic acid attenuates the phosphorylation of Erk1/2 and Akt in cervical cancer cells derived CSCs. Western blot analysis of MAPK- and PI3K/Akt pathways related proteins (total Erk1/2, pho-Erk1/2, pho-JNK, pho-p38, PI3K, total Akt, pho-Akt, total p38, and JNK) in cervical cancer cells derived CSCs and parental cervical cancer cells (a-c). Western blot analysis of total Erk1/2, pho-Erk1/2, pho-JNK, pho-p38, PI3K, total Akt, pho-Akt, total p38, and JNK in cervical cancer cells derived CSCs treated or not with 10, 20, and 30 μM zoledronic acid (d-f). Control vs. 10, 20, and 30 μM of zoledronic acid: * P < 0.05, ** P < 0.01. Results are shown as mean values ± SD of independent experiments performed in triplicate