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Table 2 Univariate and multivariate analyses of factors associated with overall survival and cumulative recurrence

From: Overexpression of RNF38 facilitates TGF-β signaling by Ubiquitinating and degrading AHNAK in hepatocellular carcinoma

Factors overall survival cumulative recurrence
  Univariate   Mulvariate   Univariate   Mulvariate  
P value HR 95%Cl P value P value HR 95% Cl P value
Gender (Female vs. Male) 0.060    NA 0.127    NA
Age (years) (≥53 vs. < 53) 0.888    NA 0.469    NA
Liver cirrhosis (yes vs. no) 0.930    NA 0.127    NA
HBsAg (positive vs. negative) 0.183    NA 0.622    NA
HCV (positive vs. negative) 0.983    NA 0.793    NA
Serum AFP, ng/mL (≥20 vs. < 20) 0.065    NA 0.011    NS
Tumor differentiation (III/IV vs. I/II) 0.197    NA 0.069    NA
Edmondson-Steiner Grade (I/II vs. III) 0.191    NA 0.018    NS
Tumor encapsulation (yes vs. no) 0.195    NA 0.043    NS
TNM stage (I/II vs. III/IV) 0.005    NS 0.086    NA
Tumor size (diameter, cm) (≥5 vs. < 5) 0.001 1.587 1.043–2.414 0.031 0.001 1.823 1.247–2.665 0.002
Embolus (Absence vs. Present) < 0.001 2.232 1.472–3.385 < 0.001 < 0.001    NS
Tumor number (multiple vs. single) 0.045    NS 0.002 2.121 1.366–3.294 0.001
RNF38 staining (high vs. low) < 0.001 2.046 1.321–3.171 0.001 0.001 1.642 1.117–2.415 0.012
  1. Abbreviations: 95% CI 95% confidence interval, AFP alpha-fetoprotein, TNM tumor node metastasis, HBsAg hepatitis B surface antigen, HCV hepatitis C virus, HR hazard ratio, NA not adopted, NS not significant
  2. Cox proportional hazards regression model