Table 2 Univariate and multivariate analyses of factors associated with overall survival and cumulative recurrence
Factors | overall survival | cumulative recurrence | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate | Mulvariate | Univariate | Mulvariate | |||||
P value | HR | 95%Cl | P value | P value | HR | 95% Cl | P value | |
Gender (Female vs. Male) | 0.060 | NA | 0.127 | NA | ||||
Age (years) (≥53 vs. < 53) | 0.888 | NA | 0.469 | NA | ||||
Liver cirrhosis (yes vs. no) | 0.930 | NA | 0.127 | NA | ||||
HBsAg (positive vs. negative) | 0.183 | NA | 0.622 | NA | ||||
HCV (positive vs. negative) | 0.983 | NA | 0.793 | NA | ||||
Serum AFP, ng/mL (≥20 vs. < 20) | 0.065 | NA | 0.011 | NS | ||||
Tumor differentiation (III/IV vs. I/II) | 0.197 | NA | 0.069 | NA | ||||
Edmondson-Steiner Grade (I/II vs. III) | 0.191 | NA | 0.018 | NS | ||||
Tumor encapsulation (yes vs. no) | 0.195 | NA | 0.043 | NS | ||||
TNM stage (I/II vs. III/IV) | 0.005 | NS | 0.086 | NA | ||||
Tumor size (diameter, cm) (≥5 vs. < 5) | 0.001 | 1.587 | 1.043–2.414 | 0.031 | 0.001 | 1.823 | 1.247–2.665 | 0.002 |
Embolus (Absence vs. Present) | < 0.001 | 2.232 | 1.472–3.385 | < 0.001 | < 0.001 | NS | ||
Tumor number (multiple vs. single) | 0.045 | NS | 0.002 | 2.121 | 1.366–3.294 | 0.001 | ||
RNF38 staining (high vs. low) | < 0.001 | 2.046 | 1.321–3.171 | 0.001 | 0.001 | 1.642 | 1.117–2.415 | 0.012 |