Fig. 1

p38MAPK signalling cascade. A multitude of extracellular stimuli and mitogens lead to the activation of p38MAPK signalling pathway consisting of a kinase network as diagrammatically represented in the figure. When activated by p38, MK2 gets exported to the cytoplasm (NLS gets masked and NES is functional) where it controls the transcript stability of tumor pathogenesis related mRNAs harbouring AREs in their 3′-UTRs via regulation of RNA-binding proteins