MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression

Table 1 MK2 regulates transcript stability via RBPs

RNA Binding Protein	Target mRNA	Influence on mRNA	References
AUF1	GM-CSF	Destabilized	[63]
	IL-6	Destabilized	[107,108,109]
	TNF-α	Destabilized	[47, 106]
	VEGF	Destabilized	[77]
HuR	COX-2	Stabilized	[90]
	Cyclins	Stabilized	[117]
	GM-CSF	Stabilized	[68]
	HIF-1α	Stabilized	[112, 113]
	IL-6	Stabilized	[120]
	IL-8	Stabilized	[120]
	MMP-9	Stabilized	[58]
	p21	Stabilized	[122]
	p27	Represses Translation	[122]
	TGF-β	Stabilized	[120]
	TNF-α	Stabilized	[120]
	VEGF	Stabilized	[113, 120]
TTP	COX-2	Destabilized	[110]
	GM-CSF	Destabilized	[68]
	IL-1	Destabilized	[107]
	IL-6	Destabilized	[107]
	IL-8	Destabilized	[107]
	MMP-9	Destabilized	[109]
	TNF-α	Destabilized	[146]
	VEGF	Destabilized	[108,109,110]

MK2 modulates the transcript stability and translation of various mRNAs (containing ARE in their 3′-UTRs) playing essential roles in various cellular and tumorigenic processes through RBP-mediated regulation as listed here. The list indicated in this table is not exhaustive but provides information about the important MK2-regulated transcripts. The numbers mentioned in brackets depict references for the same

ISSN: 1756-9966