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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Overexpression of the cohesin-core subunit SMC1A contributes to colorectal cancer development

Fig. 4

Cohesin and cancer. Abnormal cohesin activity leads to chromosome missegregation with chromosome loss and gain. These aneuploidies could alter the expression of proto-oncogenes or tumor suppressor genes. Furthermore, since cohesin binds the promoter regions of genes essential for cell cycle control, cohesin could affects directly the expression of tumor-promoting genes. These events could produce a genetic environment which favors additional changes with the acquisition of full malignant phenotype

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