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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Targeting late-stage non-small cell lung cancer with a combination of DNT cellular therapy and PD-1 checkpoint blockade

Fig. 3

DNT cells upregulate PD-1 during interaction with NSCLC. Flow cytometric analysis of PD-1 expression on T cells from resected tissue compartment of lung cancer patients’ cancer (CA), adjacent (ADJ), or normal lung tissue (NOR) (n = 10). a Frequencies of PD-1+ T cell subsets in patient lung tissue. b Comparison of tumor infiltrating PD-1+ T cells subsets in cancer tissue. Each symbol represents an individual patient, bars represent mean value. *p < 0.05, **p < 0.01, ***p < 0.001 by one-way ANOVA. C. Time course of PD-1 expression on expanded DNT cells, results of 6 independent experiments done with DNT cells expanded from 6 different donors. d Time course of PD-1 expression on expanded CD4, CD8 and DNT cells, results shown as mean ± SEM expanded from 3 different donors. *p < 0.05, **p < 0.01, ***p < 0.001, by two-tailed unpaired t-test. e PD-1 expression on DNT cells cultured alone or with various NSCLC cell lines for 48 h. One representative result of two independent experiments is shown

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