Fig. 1

AGTR1 is upregulated in ovarian cancer tissues and negatively associated with prognosis. a AGTR1 mRNA expression profile in tissues of ovarian cancer (n = 902) and healthy controls (n = 50). The data were extracted from the GENT database. The data are presented as means ± SEM, *** p < 0.001, Student’s t-test. b AGTR1 mRNA expression patterns for four independent ovarian cancer studies (GSE12172, GSE26712, GSE12471, and TCGA ovarian carcinoma project). c Representative IHC staining images of AGTR1 from different pathological subtypes of ovarian cancer (Serous n = 30, Mucinous n = 3, Clear n = 3, Borderline n = 4, Benign n = 4), Scale bar = 50 μm. d IHC scores for different pathological types were assessed according to AGTR1 cellular location and signaling intensity. e Kaplan–Meier survival analysis based on AGTR1 expression levels in ovarian cancer patients (log-rank test). Patients with top 25% expression level of AGTR1 are defined as the AGTR1 high group and the bottom 25% patients are defined as the AGTR1 low group. Median overall survival (OS) 41.63 vs 57 months, n = 294, p = 0.0301). f-h The Kaplan–Meier survival analysis (log-rank test) based on cancer grade of the patients. The higher expression level of AGTR1 had poor outcomes in the Grade 1 (OS 18.1 vs > 120 months, n = 37, p = 0.0005) and Grade 2 (OS 19.5 vs 25.3, n = 256, p = 0.0094) patients, but was not significant for Grade 3 patients (n = 1015, p = 0.097)