Fig. 6

CIC-TEX engagment in protease, adhesion molecule and related signaling regulation in CD44v6kd and Tspan8kd cells. a CIC-TEX coculture-induced ≥1.5-fold upregulated RNA expression was analyzed by KEGG for engagement in proteolysis and adhesion. The analysis was restricted to plasma membrane or plasma membrane attached proteins; proteases and inhibitors (indicated in brackets) are listed for migration; for adhesion molecules the predominant ligands are included in brackets. b Assignment of major adhesion / motility promoting signaling molecules (STRING analysis) that expression was ≥1.5-fold upregulated by CIC-TEX coculture; major targets are indicated in brackets. (Abbreviations: AJ: adherens junction, cadh: cadherin, chemok: chemokine, coll: collagen, CS: chondroitin sulphate, cytosk: cytoskeleton, FN: fibronectin, GPCR: G-protein coupled receptor, growthF: growth factors, HA: hyaluronan, inhib: inhibitor, int: integrin, LN: laminin, Synd: syndecan, List of synonyms: Additional file 1: Table S1). CIC-TEX affect proteases and more frequently adhesion molecules in v6kd and Tsp8kd cells. CIC-TEX often promote protease inhibitor upregulation. Besides matrix binding molecules, the linkage to the actin cytoskeleton and binding to cadherin is dominating. Altered adhesion molecule-promoted signaling frequently proceeds directly via activated integrins, RTK and GPCR