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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming

Fig. 8

Summary on the importance of CD44v6 and Tspan8 on CIC-TEX-promoted Non-CIC reprogramming and potential therapeutic interference. CIC-TEX promote a shift towards stem cell features in v6kd and Tsp8kd Non-CIC, CIC-TEX binding/transfer acting as a hub. The v6 importance relies on initiating activation of signal transduction and contributing to mRNA processing. Tspan8 is central in CIC-TEX communication. The complementing v6 and Tsp8 activities open new adjuvant therapeutic options by blocking CIC-TEX binding/uptake and by interfering with CIC-TEX-promoted Non-CIC activation. (CAM: cell adhesion molecules, EMT: epithelial mesenchymal transition, RTK: receptor tyrosine kinases)

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