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Table 2 Correlation between ratio of nucleus to cytoplasm TKT level and clinicopathological characteristics of 286 HCC patients

From: Transketolase (TKT) activity and nuclear localization promote hepatocellular carcinoma in a metabolic and a non-metabolic manner

Clinicopathological variables

Ratio of nucleus to cytoplasm (≥ 1versus < 1)

High total TKT level (n = 143)

 

Low total TKT level (n = 143)

≥1

< 1

p Value

 

≥1

< 1

p Value

Mean

Count

Mean

Count

 

Mean

Count

Mean

Count

Age

 

52

 

51

   

53

 

53

  

Sex

Female

 

13

 

10

0.490

  

18

 

9

0.749

 

Male

 

77

 

43

   

81

 

35

 

Cirrrhosis

Absent

 

70

 

36

0.160

  

77

 

34

0.862

 

Present

 

19

 

17

   

21

 

10

 

Maximal tumor size

< 5 cm

 

59

 

45

0.012*

  

75

 

33

0.923

 

≥ 5 cm

 

31

 

8

   

24

 

11

 

Tumor number

Single

 

83

 

50

0.632

  

92

 

43

0.249

 

Multiple

 

7

 

3

   

7

 

1

 

HBV infection

no

 

3

 

2

0.890

  

7

 

3

0.956

 

yes

 

87

 

51

.

  

92

 

41

 

Anti_HCV

negtive

 

90

 

53

.

  

98

 

44

0.503

 

positive

 

0

 

0

   

1

 

0

 

TB

< 20 μM/L

 

73

 

38

0.190

  

70

 

30

0.761

 

≥ 20 μM/L

 

17

 

15

   

29

 

14

 

AFP

< 20 ng/mL

 

29

 

19

0.660

  

30

 

17

0.328

 

≥ 20 ng/ml

 

61

 

34

   

69

 

27

 

Microvascular invasion

absent

 

44

 

28

0.650

  

70

 

33

0.598

 

present

 

46

 

25

   

29

 

11

 

Loss of Tumor encapsulation

Complete

 

38

 

27

0.310

  

54

 

28

0.310

 

Not complete

 

52

 

26

   

45

 

16

 

Child-pugh score

A Class

 

10

 

12

0.048*

  

14

 

14

0.010*

 

B or C Class

 

79

 

38

   

81

 

27

 

TNM stage

I-II

 

78

 

50

0.150

  

96

 

43

0.800

 

III-IV

 

12

 

3

   

3

 

1

 
  1. Results are based on nonempty rows and columns in each innermost subtable
  2. *The Chi-square statistic is significant at the 0.05 level