Table 3 Univariate and multivariate analysis of factors associated with disease-free survival and overall survival in 286 HCC patients

Age

0.582

1.004

0.991–1.017

0.740

1.002

0.990–1.014

Sex (female versus male)

0.795

1.054

0.710–1.563

0.221

1.247

0.876–1.777

Cirrrhosis (absent versus present)

0.524

0.892

0.627–1.268

0.312

0.845

0.611–1.170

Maximal tumor size (< 5 cm versus ≥5 cm)

0.046*

0.710

0.507-0.994

0.208

0.790

0.548–1.140

0.118

0.777

0.566–1.066

Tumor number (single versus multiple)

0.182

0.680

0.386–1.198

0.895

0.963

0.549–1.690

HBsAg (negative versus positive)

0.014*

0.448

0.236-0.850

0.170

0.532

0.216–1.311

0.017*

0.337

0.139-0.821

0.048*

0.406

0.166-0.994

Anti_HCV (negative versus positive)

0.507

0.049

0.000–359.572

0.452

20.319

0.008–52,097.066

TBIL (< 20 μM/L versus ≥20 μM/L)

0.037*

0.704

0.507-0.978

0.011*

0.644

0.459-0.904

0.081

0.760

0.559–1.034

AFP (< 20 ng/mL versus ≥20 ng/mL)

0.018*

0.673

0.484-0.935

0.176

0.788

0.559–1.113

0.013*

0.685

0.508-0.923

0.074

0.756

0.556–1.027

Vascular invasion (absent versus present)

0.002*

0.611

0.450-0.829

0.183

0.788

0.555–1.119

0.001*

0.630

0.475-0.836

0.135

0.789

0.579–1.077

Tumor encapsulation (complete versus not)

0.035*

0.722

0.534-0.977

0.158

0.798

0.584–1.091

0.028*

0.731

0.553-0.966

0.229

0.839

0.630–1.117

Child-pugh score (A versus B and C)

0.103

0.709

0.470–1.072

0.121

0.744

0.511–1.082

TNM stage(I-II versus III-IV)

< 0.001*

0.322

0.192-0.541

0.007*

0.466

0.269-0.808

0.003*

0.461

0.276-0.770

0.132

0.661

0.386–1.132

Ratio of nucleus to cytoplasm(≥ 1versus < 1)

0.012*

1.543

1.102-2.161

0.024*

1.485

1.053-2.093

0.023*

1.424

1.050-1.932

0.042*

1.38

1.011-1.885

TKT level (High versus Low)

0.023*

1.419

1.049-1.920

0.090

1.320

0.957–1.821

0.024*

1.378

1.043-1.821

0.209

1.209

0.899–1.627