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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Sequence-dependent synergistic cytotoxicity of icotinib and pemetrexed in human lung cancer cell lines in vitro and in vivo

Fig. 5

The effect of pemetrexed and icotinib on cell cycle in PC-9 cells. a The cell cycle distribution of PC-9 cells with the treatment of pemetrexed. b The cell cycle distribution of PC-9 cells with the treatment of icotinib. c The cell cycle distribution of PC-9 cells with the treatment of pemetrexed or pemetrexed followed by icotinib. d Western blot showed the changes of cyclinA, cyclinE and p27 after treatment with pemetrexed or pemetrexed followed by icotinib. The quantitative analysis was shown in the bar graphs. Data are presented as mean ± SD of triplicate experiments, *p < 0.05

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