Fig. 8

Icotinib enhanced the cytotoxicity of pemetrexed in vivo in a sequence-dependent manner. a Tumors from mice after administration of icotinib or pemetrexed alone or the two together in different sequences. b Mouse body weights after administration of icotinib or pemetrexed alone or the two together in different sequences. c Tumor volume after administration of icotinib or pemetrexed alone or the two together with in sequences. d Tumor weight after administration of icotinib or pemetrexed alone or the two together in different sequences. e Representative immunohistochemical staining of p-EGFR, p-AKT and p-ERK from tumour sections. Data are presented as mean ± S.E. * p < 0.05