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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway

Fig. 1

Effect of NF on the proliferation of GBM cells. a Different cancer cell lines were treated with NF (100 μM, 48 h), and then the percentages of viable cells were determined using MTT assay. *P < 0.05, **P < 0.01 vs. control group. b and c U87MG and U251 cells were treated with NF (0–180 μM, 0–72 h) and the inhibition rates were determined using MTT assay. d Colony formation assay was used to confirm the growth inhibitory effect of NF (0–90 μM, 3 h). e CDC2 and CD133 were decreased, and CyclinB1 was increased in GBM cells treated with NF (0–150 μM, 48 h), the expression of the indicated factors was examined by western blot. β-actin was used as the loading control. f, g and h Cell cycle assay of U87MG and U251 cells after treatment with NF (50 μM, 48 h). Data are represented as mean ± SD (n = 3), **P < 0.01

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